Journal of Neurological Sciences (Turkish) 2017 , Vol 34 , Num 1
Single-pulse Transcranial Magnetic Stimulation in Amyotrophic Lateral Sclerosis: Experience of a single institution
F.Gökçem YILDIZ1,Can Ebru Bekircan-KURT2,Kubilay VARLI2
1Hacettepe University, The Institute of Neurological Sciences and Psychiatry, Ankara, Turkey
2Hacettepe University School of Medicine , Department of Neurology, Ankara, Turkey
Objective: To investigate the assessment of cortical function changes and intrinsic circuitry in Amyotrophic Lateral Sclerosis (ALS) by transcranial magnetic stimulation (TMS).

Methods: We studied 16 ALS and 11 healthy controls by single pulse TMS from abductor digiti minimi muscle (ADM). We evaluated cortical excitability parameters including, resting motor evoked potentials (MEPs) amplitude, resting MEPs threshold , central motor conduction time (CMCT), cortical silent period duration (CSPD) and cortical silent period threshold (CSPT) in ALS.

Results: Resting MEPs threshold, CMCT, CSPT were increased in ALS patients compared to controls. CSPD was significantly shortened in ALS group.

Conclusions: TMS findings reflect the cortical hyperexcitability in ALS. Keywords : Cortical excitability, ALS, Transcranial magnetic stimulation, cortical silent period