Journal of Neurological Sciences (Turkish) 2017 , Vol 34 , Num 1
Selectins, Activated Leukocyte Cell Adhesion Molecule, and Platelet Endothelial Cell Adhesion Molecule-1 Tissue Levels in Patients With Low- and High-grade Gliomas
Taner TANRIVERDİ 1,Sima SAYYAHMELLİ 1,Rahsan KEMERDERE 1,Pinar ATUKEREN 2,Bulent EREN 3
1Istanbul University, Cerrahpasa Medical Faculty, Neurosurgery, Istanbul, Turkey
2Istanbul University, Cerrahpasa Medical Faculty, Biochemistry, Istanbul, Turkey
3Counsil of Forensic Medicine, Bursa Morgue Department, Bursa, Turkey
Background: Adhesion molecules play an important role(s) in inflammation, tumor cell progression and invasion. Here we investigated tissue levels of selectins (E-, L-, and P-selectins), activated leukocyte cell adhesion molecules (ALCAM), and platelet endothelial cell adhesion molecules-1 (PECAM-1) in a series of patients with glial tumors and controls.

Methods: A total of 39 patients, 19 with low-grade gliomas and 20 with high-grade gliomas, and 15 deceased controls who underwent autopsy after trauma were included. Adhesion molecules were measured using enzyme-linked immunosorbent assay and the results were analyzed.

Results: Statistically significant differences were found between the patients and controls regarding every molecule (p<0.05). Furthermore, significantly higher levels were found in patients with high-grade gliomas compared with those with low-grade gliomas.

Conclusion: These results suggest that adhesion molecules may have a role in glioma formation and targeted therapies could help in the treatment of these devastating brain tumors. Keywords : Adhesion molecules, ALCAM, Brain tumors, PECAM-1, Selectin