Journal of Neurological Sciences (Turkish) 2016 , Vol 33 , Num 3
An Evaluation of ABCD² Scores, Atrial Fibrillation, Serum CRP, Fibrinogen and D-Dimer Levels as Diagnostic Predictors for Stroke In Patients Admitted to Emergency Department with the Diagnosis of Transient Ischemic Attack
Miraç ÖZTÜRK1, Yücel YÜZBAŞIOĞLU1, Emine AKINCI1, Ceren TANRIKULU1, Refik KUNT2, Figen COŞKUN1
1Ankara Training and Research Hospital, Department of Emergency Medicine, Ankara, Turkey
2Aydın State Hospital, Department of Neurology, Aydın, Turkey
Introduction: This study aimed to define the roles of ABCD² score as well as other diagnostic parameters such as the presence of AF, serum fibrinogen, D-dimer and CRP levels as diagnostic predictors to determine the risk of stroke in patients diagnosed with TIA.

Materials and Methods: We performed a prospective study of 70 patients who were admitted to the emergency department at Ankara Training and Research Hospital with a diagnosis of TIA. Patients demographic data and vital signs were calculated and scores with ABCD². The blood samples for measuring CRP, D dimer and fibrinogen levels were collected. Patients were interviewed by telephone and stroke prognosis was learned after 3 months.

Results: Dysphasia (45%) and weakness (40%) were the most common presenting symptom. 52.9% of patients had moderate risk, and 12.9% had high stroke recurrence risk. 14.3% of patients have had a stroke within 3 months. AF has been detected of 10% (n:7) of all the patients and five of the seven (71.4%) patients with AF developed stroke (p<0.05). Only the CRP was targeted as possible blood predictors of stroke recurrence in TIA (p=0.008).

Conclusion: Our findings provide evidence that the ABCD² score may predict the recurrence of TIA and likelihood of having stroke after the diagnosis of TIA. Although the presence of AF, CRP, fibrinogen and D-dimer levels may be used in the diagnosis of stroke or TIA, combining the presence of AF and high-CRP levels can enhance the predictive value of ABCD² score to determine the risk of stroke. Keywords : TIA, ABCD², CRP, Fibrinogen, D-Dimer