Journal of Neurological Sciences (Turkish) 2016 , Vol 33 , Num 3
Psychopathology, Psychosocial Factors and Quality of Life in Patients with Myasthenia Gravis
Vahap Ozan KOTAN1, Zeynep KOTAN2, Birgül AYDIN3, Özlem TAŞKAPILIOĞLU4, Hamdi Necdet KARLI4, Hayriye Dilek YALVAÇ2, Güven ÖZKAYA5, Aslı SARANDÖL6, Ömer Faruk TURAN4, Selçuk KIRLI6
1Ankara Numune Training and Research Hospital, Department of Psychiatry, Ankara, Turkey
2Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Department of Psychiatry, Ankara, Turkey
3Dört Mevsim Psychological Counseling Center, Bursa, Turkey
4Uludağ University Medical Faculty, Department of Neurology, Bursa, Turkey
5Uludağ University Medical Faculty, Department of Biostatistics, Bursa, Turkey
6Uludağ University Medical Faculty, Department of Psychiatry, Bursa, Turkey
Introduction: Myasthenia Gravis (MG) is a chronic disease which affects physical, psychological and social functioning of patients. In this study we aim to determine psychiatric comorbidity, some psychosocial factors and their relations with quality of life in patients with MG.

Methods: A total of 52 patients underwent psychiatric examination and the following scales were applied: Socio-demographic data form, Hospital Anxiety and Depression Scale (HADS), Quality of Life (QOL) Scale Short Form 36 (SF-36), Psychosocial Adjustment to Illness Scale-Self report (PAIS-SR), Multidimensional Scale of Perceived Social Support (MSPSS) and Posttraumatic Growth Inventory (PTGI).

Results: Among 52 patients with MG, 36.5% (n=19) had no psychiatric diagnosis; 21.2% (n=11) had adjustment disorder; 19.2% (n=10) had depression and 23.1% (n=12) had anxiety disorder. Patients with a psychiatric diagnosis had lower scores in general health, vitality, social functioning, emotional role and mental health domains of SF-36. PAIS-SR scores, total MSPSS and friends scores were significantly higher in patients without a psychiatric diagnosis. Significant correlations of psychosocial factors with quality of life were determined.

Conclusion: In MG patients, there is a high prevalence of psychopathology and it is associated with quality of life, perceived social support and psychosocial adjustment of the patients. Quality of life is reduced in both physical and mental aspects. Diagnosis and treatment of psychopathology in MG patients is crucial to decrease disease burden. Keywords : Myasthenia gravis, psychopathology, quality of life, psychosocial factors