Journal of Neurological Sciences (Turkish) Ahead Of Print
HISTOARCHITECTURAL STUDIES OF THE VISUAL CORTEX FOLLOWING CHRONIC ADMINISTRATION OF KOLAVIRON AND NEVIRAPINE IN SPRAGUE-DAWLEY RATS.
Sunday A Ajayi1, Sunday A Ajayi 2, Onyemaechi O Azu1, Edwin CS Naidu1, Ayoola I Jegede1, Ugochukwu Offor 1
1University of KwaZulu-Natal, Discipline of Clinical Anatomy, Durban,
2Ekiti State University, Department of Anatomy, Ado-Ekiti,
DOI : 10.24165/jns.7864.14 BACKGROUND: The present study was undertaken to assess the need for indigenous antioxidant products to alleviate the necrosis of the neuron on nevirapine administered Sprague- Dawley rats METHODS: Thirty six (36) adult male Sprague-Dawley rats grouped as A-F (n=6) were used in this study. Group A received normal saline; Group B were given Nevirapine (Nv); Group C were given Kolaviron (Kv); Group D received Nv and Kv; Group E received Nv and Kv but Kv withdrawn after 28 days; Group F were given corn oil. All administrations were performed through oral gavage. Nv and Kv were administered at dosages of 1.54, and 200 mg/ kgbw respectively. The body weights were recorded every other day. Thereafter, they were anaesthetized with halothane. The brain excised, weighed, fixed in 10% formal calcium and stained with H&E. RESULTS: There was a significant (P<0.05) decrease in relative brain weights when group B compared across the groups. The histoarchitectural studies revealed, necrosis of the neurons of the occipital and frontal lobes in the cerebrum of nevirapine administered animals but normal across the groups. CONCLUSION: kolaviron, a natural antioxidant prevented the neurotoxic effects of nevirapine in the visual cortex of Sprague-Dawley rats. Keywords : Keywords: Nevirapine, Kolaviron, neurotoxicity, occipital lobe, frontal lobe