Journal of Neurological Sciences (Turkish) Ahead Of Print
Diffusion tensor imaging in early amyotrophic lateral sclerosis at 3T MRI
AYŞEGÜL SARSILMAZ1, ZEYNEP FIRAT1, AZIZ M ULUG2, GEYSU KARLIKAYA3, CANAN AYKUT BİNGÖL4, ANDAC HAMAMCI2, ILHAMI KOVANLIKAYA5
1University of Yeditepe School of Medicine, Radiology Department, Istanbul,
2Yeditepe University, Biomedical Engineering Department, Istanbul,
3Acibadem University, School of Medicine, Neurology Department, Istanbul,
4University of Yeditepe School of Medicine, Neurology Department, Istanbul,
5Weill Cornell Medical School, , Radiology Department, New York,
DOI : 10.24165/jns.9795.16 OBJECTIVE Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with impairment of white matter, corticospinal tract and frontotemporal functions such as cognition and behavior. The purpose of this study was to perform diffusion tensor imaging (DTI) for the detection of white matter microstructural abnormalities, and also understanding the pathophysiology in ALS using 3T magnetic resonance imaging. MATERIALS AND METHOD We investigated 12 patients (7 males, 5 females) with sporadic ALS and 10 control subjects (7 males, 3 females) using voxel-based analysis of DTI with 3T MRI. DTI region of interest (ROI) and tractography techniques were used to compare fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the brain corticospinal tracts between patients with ALS and healthy controls. RESULTS The patient group's results of FA and ADC measurements were 0.638±0.041 and 0.350±0.01, respectively, (p<0.001), and the healthy group's results were 0.701±0.054 and 0.288±0.027, respectively (p<0.05). DTI revealed reduced fractional anisotropy in the bilateral corticospinal tracts and internal capsule posterior crus. The FA reductions in this region correlated with the disease severity in patients with ALS. CONCLUSIONS In conclusion, longitudinal DTI study captures progression of upper motor fiber degeneration in ALS. DTI can be useful for monitoring progression and efficacy of treatment interventions, and also understanding the pathophysiology of ALS. Keywords : Keywords: Amyotrophic lateral sclerosis (ALS), diffusion tensor imaging (DTI), magnetic resonance imaging(MRI)