Effect of curcumin on passive avoidance learning disorders induced by seizure activity under chronic restraint stress in rats
Touhidi Atefeh1, Haghighizad Haydeh1, Pourmotabbed Ali1
1Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, , Kermanshah

Curcumin is a major pigment in the rhizome of curcuma longa and has several physiologic effects. It is known that repeated stress increases seizure probability in epileptic patients resulting in cognitive disorders. We have been reported the effect of chronic (for fourteen consecutive days) or acute administration of curcumin (20 mg/kg, i.p.) on pentylenetetrazole (PTZ) (60 mg/kg, i.p.)-induced seizure activity in male rats, which were hold under restraint stress (fourteen days, 2 h/day). In this study, to investigate passive avoidance learning, 24 hours later, animals were tested in shuttle-box apparatus, and their step through latencies (STL) were recorded. PTZ induced seizure or exposure to the stress per se, resulted in passive avoidance learning deficit. Stress also decreased the STL of PTZ treated animals significantly (P<0.05). Daily chronic prescription of curcumin, regardless presence or absence of stress, significantly reduced the seizure severity and improved learning ability (P<0.05). However, acute application of curcumin had no any significant effect. The results show that chronic (but not acute) application of curcumin can be effective in inhibiting seizure-induced learning disorders under chronic stress situation.

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