Association of matrix metalloproteinase-3 with lesion localization and size in acute ischemic stroke
Özyılmaz Ayşegül1, Mayda Domaç Füsun1, Mısırlı Handan1, Özkan Duygu1
1Haydarpaşa Numune Training and Research Hospital, Department of Neurology, İstanbul

Background and Purpose: The importance of molecular markers as predictors of stroke risk and ischemic damage has been increasing. Various studies suggested the association of matrix metalloproteinases with destruction of the blood brain barrier, vasogenic edema, and tissue damage in cerebral ischemia. We aimed to investigate the role of matrix metalloproteinase-3 (MMP-3) in ischemic stroke and its association with the size and localization of the infarct. Methods:The study included 30 consecutive patients who were admitted to Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey, with ischemic stroke within the 24 hours from stroke onset and 27 control subjects. In the patient group, blood samples for MMP-3 were determined at 3 different time points (within the first 24 h, between 48 to 72 h, and on the 7th day) using an enzyme-linked immunosorbent assay. Infarct size was measured using magnetic resonance imaging at 48-72 h. Statistical analyses of the data were performed using the SPSS 16.00 software package. Results: Plasma MMP-3 levels were significantly higher than the control group at all three time points (p<0.001 for all). No difference was found for MMP-3 regarding age, sex, or any vascular risk factor (p>0.05) and there was no significant correlation between MMP-3 and other laboratory parameters (r>0.05). No significant correlation was found between the lesion size and localization with serial measurements of serum MMP-3 levels (p>0.05). Conclusion: Elevation of plasma MMP-3 seems to be a useful marker for acute ischemic stroke independent of risk factors, infarct size, and localization.

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